Research

Our research is centered on the development and application of chemometric tools to tackle environmental challenges through advanced data analysis methodologies.

We can distinguish three main lines of work:

1. Chemometric Advances for Environmental Studies

We focus on developing multivariate resolution methods and data fusion strategies to analyze complex datasets from diverse analytical platforms, including:

  • Mass spectrometry (MS) with or without chromatographic separation (GC-MS, LC-MS, UHPLC-MS).
  • Hyperspectral imaging obtained through vibrational spectroscopy or MS techniques.
  • Multidimensional spectroscopies (e.g., EEM fluorescence).
  • Comprehensive multidimensional chromatographies (GC×GC-MS, LC×LC-MS).
  • Omics-based techniques such as RNA sequencing (RNAseq), proteomics, and metabolomics.
  • Integration of AI-based approaches for enhanced data analysis.

2. Environmental Monitoring & Risk Assessment

We apply these chemometric techniques to evaluate the impact of chemical pollutants and global change stressors on biological and environmental systems. This involves:

  • Large-scale environmental monitoring of legacy and emerging pollutants in water, air, soil, and sediments.
  • Assessment of pollutants in biological systems, including blood, eggs, and internal tissues from indicator species.
  • Use of bioindicators (e.g., gull eggs, fish embryos, aquatic invertebrates, and plants) to study pollutant effects over time.
  • Risk assessment by integrating data on pollution sources, environmental fate, and biological impact.

3. Environmental Omics

We leverage omics technologies to explore the biological impact of pollutants, using:

  • Chemical analysis methods (GC-MS/MS, LC-MS/MS, ICP-MS, fluorescence).
  • Chemometric strategies for data integration, pattern recognition, and mixture analysis.
  • Biological impact studies using human cell cultures, aquatic organisms (e.g., zebrafish embryos), and plant models (e.g., rice, radish).
  • Advanced omics approaches, including transcriptomics, proteomics, metabolomics, and spatial omics to analyze tissue-specific responses to pollutants.

By combining chemometrics, analytical chemistry, and environmental omics, we aim to identify pollution sources, assess environmental risks, and contribute to global environmental protection efforts.

Details on these three research lines can be found in sections «Chemometrics», «Environmental Monitoring and Risk Assessment», and «Environmental Omics».

Graphically, this can be summarized as: